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Article

Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay.

1 Nov 1990

Abstract excerpt

DNA diagnostics, the detection of specific DNA sequences, will play an increasingly important role in medicine as the molecular basis of human disease is defined. Here, we demonstrate an automated, nonisotopic strategy for DNA diagnostics using amplification of target DNA segments by the polymerase chain reaction (PCR) and the discrimination of allelic sequence variants by a colorimetric oligonucleotide ligation...

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Identifiers

PMID: 2247466
DOI: 10.1073/pnas.87.22.8923

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