Article
Fluorescent microsphere-based readout technology for multiplexed human single nucleotide polymorphism analysis and bacterial identification.
Human mutation - 1 Apr 2001
Ye F, Li M S, Taylor J D, Nguyen Q, Colton H M, Casey W M, Wagner M, Weiner M P, Chen J
Abstract excerpt
Large-scale human genotyping requires technologies with a minimal number of steps, high accuracy, and the ability to automate at a reasonable cost. In this regard, we have developed a rapid, cost-effective readout method for single nucleotide polymorphism (SNP) genotyping that combines an easily automatable single-tube allele-specific primer extension (ASPE) with an efficient high throughput flow cytometric...
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