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Article

Dual-color detection of DNA sequence variants by ligase-mediated analysis.

Genomics - 15 Mar 1994

Samiotaki M, Kwiatkowski M, Parik J, Landegren U

Abstract excerpt

Genetic screening for sequence variants associated with disease is assuming increasing importance in clinical medicine as well as in research. We describe an efficient method for such analyses, comprising a combination of practical features: (1) Amplified DNA samples are analyzed for their ability to serve as templates in standardized allele-specific ligation reactions between oligonucleotide probes; (2) Two...

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Identifiers

PMID: 7517387
DOI: 10.1006/geno.1994.1159

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