Article
Dual-color detection of DNA sequence variants by ligase-mediated analysis.
Genomics - 15 Mar 1994
Samiotaki M, Kwiatkowski M, Parik J, Landegren U
Abstract excerpt
Genetic screening for sequence variants associated with disease is assuming increasing importance in clinical medicine as well as in research. We describe an efficient method for such analyses, comprising a combination of practical features: (1) Amplified DNA samples are analyzed for their abilit...
Topics
- Base Sequence
- Colorimetry
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- DNA Ligases
- Genetic Variation
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- alpha 1-Antitrypsin