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Article

Multiplex Single-Molecule DNA Barcoding Using an Oligonucleotide Ligation Assay.

Biophysical journal - 18 Sept 2018

Severins Ivo, Szczepaniak Malwina, Joo Chirlmin

Abstract excerpt

Detection of specific nucleic acid sequences is invaluable in biological studies such as genetic disease diagnostics and genome profiling. Here, we developed a highly sensitive and specific detection method that combines an advanced oligonucleotide ligation assay with multicolor single-molecule fluorescence. We demonstrated that under our experimental conditions, 7-nucleotide long DNA barcodes have the optimal...

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Identifiers

PMID: 30195940
DOI: 10.1016/j.bpj.2018.08.013
PMCID: PMC6139880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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