Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.

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Article

Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.

Pharmacogenetics - 1 Jun 1994

Cribb A E, Isbrucker R, Levatte T, Tsui B, Gillespie C T, Renton K W

Abstract excerpt

Eighteen healthy Caucasians were evaluated for the systemic acetylation of a caffeine metabolite using the urinary caffeine metabolite ratio 5-acetylamino-6-formylamino-3-methyluracil (AFMU) to 1-methylaxanthine (1X) and for N-acetyltransferase activity in peripheral blood mononuclear leukocytes...

Topics

4-Aminobenzoic Acid
Acetylation
Adult
Arylamine N-Acetyltransferase
Biomarkers
Caffeine
Female
Humans
Isoenzymes
Kinetics
Leukocytes, Mononuclear
Male
Middle Aged
Phenotype
Substrate Specificity
Uracil
Xanthines

Source

Open in PubMed

Identifiers

PMID: 7920698

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7920698-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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