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Article

The effect of NAT2 genotype and gender on the metabolism of caffeine in nonsmoking subjects.

British journal of clinical pharmacology - 1 Mar 2000

Welfare M R, Bassendine M F, Daly A K

Abstract excerpt

AIMS: To establish whether gender or N-acetyltransferase 2 (NAT2) genotype influence the urinary 17 U+17X/137X ratio after dosing with caffeine. METHODS: Ninety-two nonsmoking individuals underwent caffeine phenotyping. NAT2 genotype was determined by the polymerase chain reaction followed by a restriction digest (PCR-RFLP). RESULTS: The median ratio for urinary 17 U+17X/137X was 6.7 (range 1.45-18. 65). 55% of...

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Share to Adolescent
Share to Arylamine N-Acetyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Stimulants

Share to Cytochrome P-450 CYP1A2

Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 10718779
DOI: 10.1046/j.1365-2125.2000.00130.x
PMCID: PMC2014918

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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