Article
Characterization of the mitochondrial DNA in patients with multiple sclerosis.
Journal of the neurological sciences - 1 Sept 1996
Kalman B, Lublin F D, Alder H
Abstract excerpt
Mitochondrial DNA (mtDNA) abnormalities with primary pathogenic significance for optic nerve atrophy have been detected in inflammatory demyelinating conditions indistinguishable from multiple sclerosis (MS). However, the degree of involvement of mtDNA alterations in the pathogenesis of MS is not clear. To further clarify this question, we sequenced the entire mtDNA in three MS patients. A number of nucleotide...
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