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Article

Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis.

Annals of neurology - 1 Jul 1994

Kellar-Wood H, Robertson N, Govan G G, Compston D A, Harding A E

Abstract excerpt

The observation of a multiple sclerosis (MS)-like illness in patients, particularly women, who carry the most common Leber's hereditary optic neuropathy mitochondrial DNA (mtDNA) mutation may indicate a contributory role for mitochondrial genes in genetic susceptibility to MS. We screened 307 unr...

Topics

Adult
Base Sequence
Brain
Comorbidity
DNA, Mitochondrial
Diseases in Twins
Family
Female
Humans
Magnetic Resonance Imaging
Male
Molecular Sequence Data
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Optic Atrophies, Hereditary

Sex Factors

Source

Identifiers

PMID: 8024249
DOI: 10.1002/ana.410360121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8024249-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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