Article
Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis.
Annals of neurology - 1 Jul 1994
Kellar-Wood H, Robertson N, Govan G G, Compston D A, Harding A E
Abstract excerpt
The observation of a multiple sclerosis (MS)-like illness in patients, particularly women, who carry the most common Leber's hereditary optic neuropathy mitochondrial DNA (mtDNA) mutation may indicate a contributory role for mitochondrial genes in genetic susceptibility to MS. We screened 307 unrelated MS patients, ascertained from population surveys, for the pathogenic Leber's hereditary optic neuropathy...
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