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Article

Characterization of the mitochondrial genome in childhood multiple sclerosis. I. Optic neuritis and LHON mutations.

Neuropediatrics - 1 Aug 1998

Ohlenbusch A, Wilichowski E, Hanefeld F

Abstract excerpt

The occurrence of optic neuropathy in patients with MS-like disorders who carry one of the pathogenetically significant LHON mutations as well as the higher incidence of maternal transmission in familial cases of MS support the hypothesis that mitochondrial genes may be implicated in susceptibility to MS. We sequenced the entire mtDNA of six children with MS who developed optic neuritis as early and prominent...

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Share to Child
Share to DNA, Mitochondrial
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Human

Share to Multiple Sclerosis

Share to Mutation

Share to Optic Atrophies, Hereditary

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 9762692
DOI: 10.1055/s-2007-973557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of the mitochondrial genome in childhood multiple sclerosis. I. Optic neuritis and LHON mutations.PMID 9762692Read ↗

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