Characterization of the mitochondrial genome in childhood multiple sclerosis. I. Optic neuritis and LHON mutations.

doi:10.1055/s-2007-973557

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Article

Characterization of the mitochondrial genome in childhood multiple sclerosis. I. Optic neuritis and LHON mutations.

Neuropediatrics - 1 Aug 1998

Ohlenbusch A, Wilichowski E, Hanefeld F

Abstract excerpt

The occurrence of optic neuropathy in patients with MS-like disorders who carry one of the pathogenetically significant LHON mutations as well as the higher incidence of maternal transmission in familial cases of MS support the hypothesis that mitochondrial genes may be implicated in susceptibili...

Topics

Child
DNA, Mitochondrial
Female
Genetic Predisposition to Disease
Genome, Human
Humans
Male
Multiple Sclerosis
Mutation
Optic Atrophies, Hereditary
Optic Neuritis
Sequence Analysis, DNA

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