Article
Analysis of the entire mitochondrial genome reveals Leber's hereditary optic neuropathy mitochondrial DNA mutations in an Arab cohort with multiple sclerosis.
Scientific reports - 30 Jun 2022
Al-Kafaji Ghada, Alharbi Maram A, Alkandari Hasan, Salem Abdel Halim, Bakhiet Moiz
Abstract excerpt
Several mitochondrial DNA (mtDNA) mutations of Leber's hereditary optic neuropathy (LHON) have been reported in patients with multiple sclerosis (MS) from different ethnicities. To further study the involvement of LHON mtDNA mutations in MS in the Arab population, we analyzed sequencing data of the entire mitochondrial genome from 47 unrelated Saudi individuals, 23 patients with relapse-remitting MS (RRMS) and 24...
Topics
- Arabs
- DNA, Mitochondrial
- Genome, Mitochondrial
- Humans
- Multiple Sclerosis
- Mutation
- Neoplasm Recurrence, Local
- Optic Atrophy, Hereditary, Leber