Mitochondrial DNA mutations in multiple sclerosis patients with severe optic involvement

Abstract excerpt

UNLABELLED: Preferential maternal transmission in familial cases and the occasional association of multiple sclerosis (MS) and LHON suggests an involvement of mtDNA mutations in the aetiology of MS. MATERIAL & METHODS: DNA obtained from 100 MS patients with pathological alterations in visually evoked potentials and 100 controls, was used for PCR amplification of mtDNA segments. Mutations were identified by...

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