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Article

Voltage-dependent inhibition of outward Kir2.1 currents by extracellular spermine.

Biochimica et biophysica acta - 1 Feb 2013

Chang Hsueh-Kai, Shieh Ru-Chi

Abstract excerpt

Outward currents through inward rectifier Kir2.1 channels play crucial roles in controlling the electrical properties of excitable cells. Extracellular monovalent and divalent cations have been shown to reduce outward K(+) conductance. In the present study, we examined whether spermine, with four positive charges, also inhibits outward Kir2.1 currents. We found that extracellular spermine inhibits steady-state...

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Identifiers

PMID: 22948070
DOI: 10.1016/j.bbamem.2012.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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