Article
Increased levels of kynurenic acid in brains of genetically dystonic hamsters.
Brain research. Developmental brain research - 29 Mar 1996
Richter A, Loscher W, Baran H, Gramer M
Abstract excerpt
Recent pharmacological studies have shown antidystonic effects of NMDA and non-NMDA receptor antagonists in an inbred line of Syrian hamsters (dt(sz)) with primary generalized dystonia, i.e. a neurological syndrome of sustained muscle contractions which occurs in the absence of any pathomorphological alterations. This prompted us to examine the levels of kynurenic acid (KYNA), the endogenous broad spectrum...
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