Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia.

European journal of pharmacology - 3 Nov 1994

Richter A, Löschmann P A, Löscher W

Abstract excerpt

Recent findings of antidystonic effects of NMDA and non-NMDA receptor antagonists in an inbred line of Syrian hamsters with primary generalized dystonia prompted us to investigate the effects of lamotrigine, an inhibitor of veratrine-induced glutamate release, on the severity of dystonia in mutant hamsters. In mutant dystonic hamsters the dystonic attacks which can be induced by mild environmental stimuli or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cricetinae
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Mesocricetus

Share to Motor Activity

Share to Mutation

Share to Time Factors

Source

Identifiers

PMID: 7698175
DOI: 10.1016/0014-2999(94)00493-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia.PMID 7698175Read ↗

Increased levels of kynurenic acid in brains of genetically dystonic hamsters.Semantic proximity Read ↗

Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.Semantic proximity Read ↗

Piracetam and levetiracetam, two pyrrolidone derivatives, exert antidystonic activity in a hamster model of paroxysmal dystonia.Semantic proximity Read ↗

Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.Semantic proximity Read ↗

Effects of pharmacological manipulation of dopaminergic and cholinergic neurotransmission in genetically dystonic hamsters.Semantic proximity Read ↗

Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dtsz) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.Semantic proximity Read ↗

MK-801 potentiates antidystonic effects of clozapine but not of haloperidol in mutant dystonic hamsters.Semantic proximity Read ↗

The atypical neuroleptic, clozapine, exerts antidystonic activity in a mutant hamster model. Comparison with haloperidol.Semantic proximity Read ↗

Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.Semantic proximity Read ↗

Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.Semantic proximity Read ↗

Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.Semantic proximity Read ↗

Neuropathological studies in a mutant hamster model of paroxysmal dystonia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.