Article
The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia.
European journal of pharmacology - 3 Nov 1994
Richter A, Löschmann P A, Löscher W
Abstract excerpt
Recent findings of antidystonic effects of NMDA and non-NMDA receptor antagonists in an inbred line of Syrian hamsters with primary generalized dystonia prompted us to investigate the effects of lamotrigine, an inhibitor of veratrine-induced glutamate release, on the severity of dystonia in mutant hamsters. In mutant dystonic hamsters the dystonic attacks which can be induced by mild environmental stimuli or...
Topics
- Administration, Oral
- Aging
- Animals
- Anticonvulsants
- Cricetinae
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Dystonia
- Injections, Intraperitoneal
- Lamotrigine
- Mesocricetus