Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.

doi:10.1046/j.1471-4159.1995.64052153.x

Back to search

Article

Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.

Journal of neurochemistry - 1 May 1995

Pratt G D, Richter A, Möhler H, Löscher W

Abstract excerpt

Previous pharmacological studies have indicated that impairment of GABAergic transmission may be involved in the pathophysiology of dystonia in the mutant dtsz hamster, i.e., a genetic animal model for idiopathic dystonia. In the present experiments, the kinetic constants of [3H]flumazenil bindin...

Topics

Aging
Animals
Binding Sites
Brain
Cerebellum
Corpus Striatum
Cricetinae
Disease Models, Animal
Dystonia
Flumazenil
Frontal Lobe
Kinetics
Mutation
Olfactory Bulb
Receptors, GABA-A
Superior Colliculi
Tritium

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.