Article
Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.
Journal of neurochemistry - 1 May 1995
Pratt G D, Richter A, Möhler H, Löscher W
Abstract excerpt
Previous pharmacological studies have indicated that impairment of GABAergic transmission may be involved in the pathophysiology of dystonia in the mutant dtsz hamster, i.e., a genetic animal model for idiopathic dystonia. In the present experiments, the kinetic constants of [3H]flumazenil binding to the benzodiazepine site of the GABAA receptor were calculated from equilibrium binding measurements in various...
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