Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

doi:10.1016/j.ejphar.2008.02.052

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Article

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

European journal of pharmacology - 31 May 2008

Hamann Melanie, Sander Svenja E, Richter Angelika

Abstract excerpt

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic episodes. Previous examinations have shown changes in kynurenic acid levels and antidystonic effects of the kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfon-amide (Ro...

Topics

Animals
Cricetinae
Dystonia
Enzyme Inhibitors
Kynurenine 3-Monooxygenase
Microinjections
Mutation
Neostriatum
Sulfonamides
Thiazoles

Source

Open in PubMed

Identifiers

PMID: 18353306
DOI: 10.1016/j.ejphar.2008.02.052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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