Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

European journal of pharmacology - 31 May 2008

Hamann Melanie, Sander Svenja E, Richter Angelika

Abstract excerpt

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic episodes. Previous examinations have shown changes in kynurenic acid levels and antidystonic effects of the kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfon-amide (Ro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cricetinae
Share to Dystonia
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microinjections

Share to Mutation

Share to Neostriatum

Share to Sulfonamides

Share to Thiazoles

Source

Identifiers

PMID: 18353306
DOI: 10.1016/j.ejphar.2008.02.052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.PMID 18353306Read ↗

Autoradiographic and pharmacological studies on the role of dopamine D3 receptors in genetically dystonic (dt(sz)) hamsters.Semantic proximity Read ↗

Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.Semantic proximity Read ↗

Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.Semantic proximity Read ↗

The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant.Semantic proximity Read ↗

Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dtsz) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.Semantic proximity Read ↗

Polyamines in a genetic animal model of paroxysmal dyskinesia.Semantic proximity Read ↗

Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.Semantic proximity Read ↗

Extracellular amino acid levels in the striatum of the dt(sz) mutant, a model of paroxysmal dystonia.Semantic proximity Read ↗

Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.Semantic proximity Read ↗

Increased levels of kynurenic acid in brains of genetically dystonic hamsters.Semantic proximity Read ↗

Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.Semantic proximity Read ↗

Effects of pharmacological manipulation of dopaminergic and cholinergic neurotransmission in genetically dystonic hamsters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.