Article
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
European journal of pharmacology - 10 Jan 1991
Fredow G, Löscher W
Abstract excerpt
Attacks of sustained dystonic postures of limbs and trunk can be initiated by handling or mild environmental stimuli (e.g. new cage) in an inbred line of Syrian hamsters. The severity of the dystonic syndrome in these mutant hamsters (gene symbol dtsz) is age-dependent, with a peak at about 30-40 days of age. A scoring system for grading type and severity of the dystonic attacks can be used to study the activity...
Topics
- Animals
- Baclofen
- Carbamazepine
- Cricetinae
- Diazepam
- Disease Models, Animal
- Dystonia
- Mesocricetus
- Mutation
- Pentylenetetrazole
- Phenobarbital
- Phenytoin