Article
Extracellular amino acid levels in the striatum of the dt(sz) mutant, a model of paroxysmal dystonia.
Neuroscience - 11 Nov 2008
Hamann M, Sohr R, Morgenstern R, Richter A
Abstract excerpt
The pathophysiology of idiopathic dystonia is still unknown, but it is regarded as a basal ganglia disorder. Previous studies indicated an involvement of a striatal GABAergic disinhibition and a cortico-striatal glutamatergic overactivity in the manifestation of stress-inducible dystonic episodes in the dt(sz) hamster, a model of idiopathic paroxysmal dystonia. These investigations were carried out postmortem or...
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