Article
Effects of pharmacological manipulation of dopaminergic and cholinergic neurotransmission in genetically dystonic hamsters.
European journal of pharmacology - 17 Mar 1992
Löscher W, Fredow G
Abstract excerpt
In an inbred line of Syrian hamsters, attacks of sustained dystonic postures of the limbs and trunk can be initiated by handling or mild environmental stimuli (e.g. new cage). The severity of the dystonic syndrome in these mutant hamsters (gene symbol dtSZ) is age-dependent, with a peak at about 30-40 days of age. A scoring system for grading the type and severity of the dystonic attacks can be used to study the...
Topics
- Acetylcholine
- Animals
- Apomorphine
- Behavior, Animal
- Carbidopa
- Cricetinae
- Dopamine
- Drug Interactions
- Dystonia
- Haloperidol
- Levodopa
- Mesocricetus