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Article

Polyamines in a genetic animal model of paroxysmal dyskinesia.

Brain research - 15 Aug 2003

Richter Angelika, Morrison Lesley D

Abstract excerpt

Previous studies suggested that glutamatergic overactivity contributes to the manifestation of dystonia in the dt(sz) mutant hamster, a model of idiopathic paroxysmal dyskinesia in which dystonic episodes occur in response to mild stress. Therefore, the role of polyamines, known as positive modulators of NMDA receptors, was examined in the present study. The levels of polyamines (putrescine, spermidine, spermine)...

Topics

Aging
Animals
Brain
Case-Control Studies
Chorea
Cricetinae
Disease Models, Animal
Dose-Response Relationship, Drug
Dystonia
Excitatory Amino Acid Agents
Mutation
Piperidines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polyamines

Receptors, N-Methyl-D-Aspartate

Severity of Illness Index

Source

Identifiers

PMID: 12885438
DOI: 10.1016/s0006-8993(03)03022-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Polyamines in a genetic animal model of paroxysmal dyskinesia.PMID 12885438Read ↗

The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant.Semantic proximity Read ↗

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