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Article

Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.

European journal of pharmacology - 3 Oct 2005

Kreil Annette, Richter Angelika

Abstract excerpt

In the dtsz mutant hamster, a model of paroxysmal dyskinesia in which dystonic episodes occur in response to stress, previous studies suggested that retarded development of gamma-aminobutyric acid (GABA)ergic inhibition plays a critical role in the pathogenesis. In the present study, we therefore examined the effects of selective GABA uptake inhibitors on severity of dystonia in dtsz hamsters....

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Identifiers

PMID: 16183056
DOI: 10.1016/j.ejphar.2005.08.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.PMID 16183056Read ↗

The carbonic anhydrase inhibitor acetazolamide exerts antidystonic effects in the dt(sz) mutant hamster.Semantic proximity Read ↗

Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.Semantic proximity Read ↗

Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.Semantic proximity Read ↗

Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.Semantic proximity Read ↗

The α2β3γ2 GABAA receptor preferring agonist NS11394 aggravates dystonia in the phenotypic dtsz model.Semantic proximity Read ↗

Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.Semantic proximity Read ↗

MK-801 potentiates antidystonic effects of clozapine but not of haloperidol in mutant dystonic hamsters.Semantic proximity Read ↗

Polyamines in a genetic animal model of paroxysmal dyskinesia.Semantic proximity Read ↗

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.Semantic proximity Read ↗

Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dtsz) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics.Semantic proximity Read ↗

The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant.Semantic proximity Read ↗

Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.Semantic proximity Read ↗

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