Article
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
European journal of pharmacology - 26 Jan 1993
Richter A, Löscher W
Abstract excerpt
Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e.g. new cage) in mutant (gene symbol dtsz) Syrian golden hamsters. The severity of the dystonic syndrome in these mutant hamsters is age-dependent, with a peak at weaning (21 days of...
Topics
- Aging
- Aminooxyacetic Acid
- Animals
- Cricetinae
- Diazepam
- Dopamine Antagonists
- Dystonia
- Mesocricetus
- Mutation
- Phenobarbital
- Receptors, Dopamine
- Receptors, GABA-A
- Receptors, Glutamate
- Receptors, N-Methyl-D-Aspartate
- Remission, Spontaneous
- Sensitivity and Specificity