Article
Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1996
Brown P H, Kim S H, Wise S C, Sabichi A L, Birrer M J
Abstract excerpt
We have previously described a dominant-negative mutant of cJun that lacks the transactivation domain (TAD) of cJun and prevents AP-1-mediated transcriptional activation by quenching endogenous Jun or Fos proteins. We now report the development of a panel of cJun mutants that have inactivating mutations in the TAD, DNA-binding domain (DBD), or leucine zipper domain. These mutants are all unable to activate...
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