Article
Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1996
Brown P H, Kim S H, Wise S C, Sabichi A L, Birrer M J
Abstract excerpt
We have previously described a dominant-negative mutant of cJun that lacks the transactivation domain (TAD) of cJun and prevents AP-1-mediated transcriptional activation by quenching endogenous Jun or Fos proteins. We now report the development of a panel of cJun mutants that have inactivating mu...
Topics
- Animals
- Cells, Cultured
- DNA-Binding Proteins
- Dimerization
- Genes, ras
- Mutation
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Rats
- Structure-Activity Relationship
- Tetradecanoylphorbol Acetate
- Transcription Factor AP-1
- Transcription, Genetic
- Transformation, Genetic