Article
Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1994
Domann F E, Levy J P, Birrer M J, Bowden G T
Abstract excerpt
We have stably expressed a trans-activation suppressing deletion mutant of the human c-jun gene (TAM-67) in the malignant mouse epidermal cell lines 10Gy5 and PDV. Expression of the p26 mJUN protein blocked both constitutive and inducible transcriptional trans-activation of several AP-1 responsiv...
Topics
- Animals
- DNA, Neoplasm
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, jun
- Humans
- Mice
- Mice, Nude
- Mutation
- Phenotype
- Plasmids
- Proto-Oncogene Proteins c-jun
- Tumor Cells, Cultured