Article
Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2002
Omura Takashi, Yoshiyama Minoru, Yoshida Ken, Nakamura Yasuhiro, Kim Shokei, Iwao Hiroshi, Takeuchi Kazuhide, Yoshikawa Junichi
Abstract excerpt
The activator protein 1 (AP-1) transcriptional complex, containing Jun and Fos proteins, is involved in regulating many cellular processes such as proliferation and differentiation. However, little is known about a direct relationship between AP-1 activities and cardiomyocyte hypertrophy. To elucidate the roles of myocardial AP-1 activities, dominant negative mutant of c-Jun (DNJun) was overexpressed in cultured...
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