Article
cFos is critical for MCF-7 breast cancer cell growth.
Oncogene - 29 Sept 2005
Lu Chunhua, Shen Qiang, DuPré Elizabeth, Kim Heetae, Hilsenbeck Susan, Brown Powel H
Abstract excerpt
The activating protein-1 (AP-1) transcription factor is a converging point of multiple signal transduction pathways in many cells. We have previously demonstrated that overexpressing Tam67, a dominant-negative (DN) form of cJun, blocks AP-1 activity and inhibits breast cancer cell growth. We hypothesized that Tam67 forms dimers with other AP-1 proteins to suppress the growth of breast cancer cells. In the present...
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