Article
Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1990
Yang D M, Fairweather N, Button L L, McMaster W R, Kahl L P, Liew F Y
Abstract excerpt
The gp63 gene of Leishmania major was transformed into the AroA- vaccine strain of Salmonella typhimurium (SL3261). The construct (SL3261-gp63), which stably expresses the gp63 Ag in vitro, was used to immunize CBA mice by the oral route. Spleen cells from mice inoculated with SL3261-gp63 develop...
Topics
- Administration, Oral
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Cloning, Molecular
- Leishmania tropica
- Leishmaniasis
- Lymphocyte Activation
- Mice
- Mice, Inbred CBA
- Mutation
- Salmonella typhimurium
- Spleen
- T-Lymphocytes, Helper-Inducer
- Vaccines, Attenuated
- Vaccines, Synthetic