Article
Use of Salmonella for heterologous gene expression and vaccine delivery systems.
Current opinion in biotechnology - 1 Oct 1993
Hackett J
Abstract excerpt
In the past year, the importance of secretory IgA has been emphasized as fundamental to protection against oral Salmonella infection. In several human trials, aro mutants of Salmonella typhi were highly immunogenic, but still retained the capacity to proceed beyond the gut wall after ingestion. Epitopes of Shiga toxin and influenza hemagglutinin have been expressed in Salmonella surface proteins in work aimed at...
Topics
- Animals
- Antigens, Bacterial
- Biotechnology
- Gene Expression
- Humans
- Immunoglobulin A, Secretory
- Mutation
- Recombinant Proteins
- Salmonella
- Salmonella Infections
- Vaccines, Synthetic
- Virulence