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[Attenuated Salmonella typhimurium as DNA delivery vehicle for DNA-mediated immunization].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Sept 2004

He Ping, Chen Hong, Liu Jing-xing, Chen Shu-yun, Hu Bao-yu

Abstract excerpt

OBJECTIVE: To study whether the live attenuated AroA-auxotrophic mutant of Salmonella (S.) typhimurium (SL7207) could be used as DNA delivery vehicle to induce more efficient immune response by using the eukaryotic expression plasmid pCMV-beta as report gene. METHODS: Murine peritoneal macrophages were infected with SL7207(pCMV-beta) in vitro, then the expression of the beta-gal were detected by X-gal staining or...

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PMID: 15640857

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