Article
Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant.
Infection and immunity - 1 Jul 1998
Valentine P J, Devore B P, Heffron F
Abstract excerpt
A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the pane...
Topics
- 3-Phosphoshikimate 1-Carboxyvinyltransferase
- Alkyl and Aryl Transferases
- Animals
- Antibodies, Bacterial
- Bacterial Vaccines
- Female
- Hypersensitivity, Delayed
- Immunoglobulin A, Secretory
- Immunoglobulin G
- Mice
- Mice, Inbred BALB C
- Mutation
- Salmonella typhimurium
- Vaccines, Attenuated