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Article

Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant.

Infection and immunity - 1 Jul 1998

Valentine P J, Devore B P, Heffron F

Abstract excerpt

A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of mutants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher...

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Source

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Identifiers

PMID: 9632608
DOI: 10.1128/IAI.66.7.3378-3383.1998
PMCID: PMC108355

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Source receipt: pubmed, retrieved 7 Sept 2026.

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