Article
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
Folia histochemica et cytobiologica - 1 Jan 2001
Kovalchuk O, Naumnik W, Serwicka A, Chyczewska E, Niklinski J, Chyczewski L
Abstract excerpt
We investigated the presence of K-ras mutations in the serum of 40 patients with respectable stages of adeno- and large cell lung carcinomas. Mutations in codon 12 of the K-ras gene were examined by enriched PCR method in DNA extracts from surgical specimens and serum samples. K-ras mutations were detected in 20 (51%) of 39 analyzed tumours, and in 7 (35%) of 20 patients with K-ras gene mutation positive tumours,...
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