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Article

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2010

D'Amico Gabriela, Korhonen Emilia Anne, Waltari Marika, Saharinen Pipsa, Laakkonen Pirjo, Alitalo Kari

Abstract excerpt

OBJECTIVE: Studies of Tie1 gene-targeted embryos have demonstrated loss of blood vessel integrity, but the relevance of Tie1 in lymphatic vasculature development is unknown. We tested the hypothesis that the swelling observed in Tie1 mutant embryos is associated with lymphatic vascular defects. METHODS AND RESULTS: We could extend the survival of the Tie1-deficient embryos in the ICR background, which allowed us...

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Identifiers

PMID: 19910638
DOI: 10.1161/ATVBAHA.109.196618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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