Article
Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas.
Journal of autoimmunity - 1 Feb 1996
Bui M M, Luo D F, She J Y, Maclaren N K, Muir A, Thomson G, She J X
Abstract excerpt
Whereas it is well known that the insulin gene (INS) region at 11p15.5 (IDDM2) confers susceptibility to insulin-dependent diabetes mellitus (IDDM), it is still controversial whether the parental origin of IDDM2 influences IDDM susceptibility. We have analysed the Pst I + 1127 polymorphism in 123...
Topics
- Alleles
- Base Sequence
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Gene Expression Regulation
- Genetic Linkage
- Humans
- Insulin
- Molecular Sequence Data
- Pancreas
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sex Factors