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Article

IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).

Autoimmunity - 1 Jan 1999

Larsen Z M, Kristiansen O P, Mato E, Johannesen J, Puig-Domingo M, de Leiva A, Nerup J, Pociot F

Abstract excerpt

Type 1 diabetes (insulin-dependent) is a multifactorial disease with polygenic susceptibility. The major genetic component (IDDM1) resides within the HLA region, but several non-HLA loci have been implicated in the genetic susceptibility. In the present study, we have analysed two such loci, IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34, in Danish (n = 254) and Spanish (n = 39) type 1 diabetic multiplex families. No...

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Source

Identifiers

PMID: 10593567
DOI: 10.3109/08916939908993857

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).PMID 10593567Read ↗

A linkage study of 12 IDDM susceptibility loci in the Finnish population.Semantic proximity Read ↗

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.Semantic proximity Read ↗

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.Semantic proximity Read ↗

PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians.Semantic proximity Read ↗

Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.Semantic proximity Read ↗

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses.Semantic proximity Read ↗

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14th International HLA and Immunogenetics Workshop: report on the HLA component of type 1 diabetes.Semantic proximity Read ↗

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