Article
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.
Nature genetics - 1 Mar 1995
Bennett S T, Lucassen A M, Gough S C, Powell E E, Undlien D E, Pritchard L E, Merriman M E, Kawaguchi Y, Dronsfield M J, Pociot F
Abstract excerpt
The IDDM2 locus encoding susceptibility to type 1 diabetes was mapped previously to a 4.1-kb region spanning the insulin gene and a minisatellite or variable number of tandem repeats (VNTR) locus on human chromosome 11p15.5. By 'cross-match' haplotype analysis and linkage disequilibrium mapping,...
Topics
- Adult
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA
- DNA Primers
- DNA, Satellite
- Diabetes Mellitus, Type 1
- Female
- Gene Expression
- Genomic Imprinting
- Haplotypes
- Humans
- Insulin