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Article

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.

Nature genetics - 1 Mar 1995

Bennett S T, Lucassen A M, Gough S C, Powell E E, Undlien D E, Pritchard L E, Merriman M E, Kawaguchi Y, Dronsfield M J, Pociot F

Abstract excerpt

The IDDM2 locus encoding susceptibility to type 1 diabetes was mapped previously to a 4.1-kb region spanning the insulin gene and a minisatellite or variable number of tandem repeats (VNTR) locus on human chromosome 11p15.5. By 'cross-match' haplotype analysis and linkage disequilibrium mapping, we have mapped the mutation IDDM2 to within the VNTR itself. Other polymorphisms were systematically excluded as...

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PMID: 7773291
DOI: 10.1038/ng0395-284

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Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.PMID 7773291Read ↗

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The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcriptionSemantic proximity Read ↗

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Remapping the insulin gene/IDDM2 locus in type 1 diabetes.Semantic proximity Read ↗

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.Semantic proximity Read ↗

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Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

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