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Article

Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus.

Diabetologia - 1 Jun 1995

Polychronakos C, Kukuvitis A, Giannoukakis N, Colle E

Abstract excerpt

Although association of insulin-dependent diabetes mellitus with a haplotype at a locus encompassing the genes for insulin and the insulin-like growth factor II has been well established, two major studies disagree as to whether linkage to this locus is confined to paternally inherited alleles, or is present in alleles transmitted from either parental sex. Towards resolving this discrepancy, we examined...

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Identifiers

PMID: 7672495
DOI: 10.1007/BF00401845

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus.PMID 7672495Read ↗

Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas.Semantic proximity Read ↗

The analysis of parental origin of alleles may detect susceptibility loci for complex disorders.Semantic proximity Read ↗

Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.Semantic proximity Read ↗

Functional Polymorphism in the Parental Imprinting of the Human IGF2R GeneSemantic proximity Read ↗

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Evidence that insulin is imprinted in the human yolk sac.Semantic proximity Read ↗

The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect.Semantic proximity Read ↗

Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects.Semantic proximity Read ↗

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting.Semantic proximity Read ↗

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