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Article

Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra.

Antimicrobial agents and chemotherapy - 1 Aug 1996

Kocagöz T, Hackbarth C J, Unsal I, Rosenberg E Y, Nikaido H, Chambers H F

Abstract excerpt

To characterize mechanisms of resistance to fluoroquinolones by Mycobacterium tuberculosis, mutants of strain H37Ra were selected in vitro with ofloxacin. Their quinolone resistance-determining regions for gyrA and gyrB were amplified and sequenced to identify mutations in gyrase A or B. Three types of mutants were obtained: (i) one mutant (TKp1) had no mutations in gyrA or gyrB; (ii) mutants that had single...

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Identifiers

PMID: 8843279
DOI: 10.1128/AAC.40.8.1768
PMCID: PMC163415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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