Article
Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients.
Antimicrobial agents and chemotherapy - 1 Aug 1995
Alangaden G J, Manavathu E K, Vakulenko S B, Zvonok N M, Lerner S A
Abstract excerpt
To examine the mechanism of resistance to fluoroquinolones in Mycobacterium tuberculosis, we selected spontaneous fluoroquinolone-resistant mutants from a susceptible strain, H37Rv, and studied the susceptibilities of these mutants and two fluoroquinolone-resistant clinical isolates (A-382, A-564...
Topics
- Aged
- Aged, 80 and over
- Anti-Infective Agents
- Base Sequence
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Female
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Polymerase Chain Reaction