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Article

Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74.

Antimicrobial agents and chemotherapy - 1 Feb 2011

Lau Ricky W T, Ho Pak-Leung, Kao Richard Y T, Yew Wing-Wai, Lau Terrence C K, Cheng Vincent C C, Yuen Kwok-Yung, Tsui Stephen K W, Chen Xinchun, Yam Wing-Cheong

Abstract excerpt

A PCR-sequencing assay was evaluated for direct detection of mutations in the quinolone resistance-determining region (QRDR) of gyrase A (gyrA) gene in fluoroquinolone-resistant Mycobacterium tuberculosis in respiratory specimens. As determined by gyrA QRDR analysis, complete concordance of genotypic and phenotypic fluoroquinolone resistance was demonstrated. Our results indicate that the assay is a rapid and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20956608
DOI: 10.1128/AAC.00920-10
PMCID: PMC3028802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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