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Article

Development and mechanism of fluoroquinolone resistance in Legionella pneumophila.

The Journal of antimicrobial chemotherapy - 1 Feb 2003

Jonas Daniel, Engels Inge, Hartung Doris, Beyersmann Jan, Frank Uwe, Daschner Franz D

Abstract excerpt

The potential for selection in vitro of Legionella pneumophila mutants resistant to fluoroquinolones was investigated. Six distinct clinical isolates of L. pneumophila were subcultured in subinhibitory concentrations of ciprofloxacin, levofloxacin, clinafloxacin, trovafloxacin and moxifloxacin until MICs increased at least eight-fold. The numbers of serial passages required in microbroth dilution series were...

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Identifiers

PMID: 12562691
DOI: 10.1093/jac/dkg054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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