Tumor-suppressor p53: implications for tumor development and prognosis.

doi:10.1200/JCO.1998.16.9.3158

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Article

Tumor-suppressor p53: implications for tumor development and prognosis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 1998

Kirsch D G, Kastan M B

Abstract excerpt

The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 g...

Topics

Apoptosis
Cell Cycle
Genes, p53
Humans
Mutation
Neoplasms
Prognosis
Tumor Suppressor Protein p53

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