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Article

p53 tumor-suppressor gene: Clues to molecular carcinogenesis

1 Nov 1997

Abstract excerpt

The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. The p53 is functionally inactivated by mutational, viral, and cellular mechanisms in the majority of human cancers. Analysis of the spectrum of p53 mutations provides clues to the etiology...

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Identifiers

PMID: 9365531
DOI: 10.1002/(sici)1097-4652(199711)173:2<247::aid-jcp30>3.0.co;2-a

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