The role of p53 in human cancer.

doi:10.1023/a:1010636426860

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Article

The role of p53 in human cancer.

Journal of neuro-oncology - 1 Feb 2001

Malkin D

Abstract excerpt

In the two decades since its original discovery, p53 has found a singularly prominent place in our understanding of human cancer. Although the biochemistry of p53 has been worked out in some detail, our knowledge of the biologic consequences of p53 dysfunction is still quite rudimentary. Over the next several years, it will be important to determine how best to harness the complex properties of p53's ability to...

Topics

Animals
Genes, Tumor Suppressor
Germ-Line Mutation
Humans
Li-Fraumeni Syndrome
Mutation
Neoplasms
Pedigree
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 11407595
DOI: 10.1023/a:1010636426860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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