Article
Regulation and function of the p53 tumor suppressor protein.
Current opinion in cell biology - 1 Jun 2001
Ryan K M, Phillips A C, Vousden K H
Abstract excerpt
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
Topics
- Active Transport, Cell Nucleus
- Animals
- Apoptosis
- Cell Compartmentation
- Cell Cycle
- Cell Division
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Neoplasms
- Transcription Factors
- Transcription, Genetic
- Tumor Suppressor Protein p53