Article
TP53 tumour suppressor gene: clues to molecular carcinogenesis and cancer therapy.
Cancer surveys - 1 Jan 1996
Wang X W, Harris C C
Abstract excerpt
The tumour suppressor gene product TP53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell cycle control and apoptosis, that are central to human carcinogenesis. TP53 is functionally inactivated by mutational, viral and cellular me...
Topics
- Animals
- Apoptosis
- Cell Division
- DNA Repair
- Genes, p53
- Humans
- Li-Fraumeni Syndrome
- Mice
- Mutation
- Neoplasms
- Phosphorylation
- Transcription, Genetic
- Tumor Suppressor Protein p53