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Article

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.

Haemostasis - 1 Oct 1996

Dahlbäck B, Zöller B, Hillarp A

Abstract excerpt

Inherited resistance to activated protein C (APC) was recently discovered as a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. In a majority of cases, APC resistance is associated with a single point mutation in the factor V gene, which results in substitution of arginine (R) at position 506 by glutamine (Q) (FV:Q506). The mutation renders factor...

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PMID: 8979136
DOI: 10.1159/000217311

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.PMID 8979136Read ↗

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Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.Semantic proximity Read ↗

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Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C caused by a factor V gene mutation.Semantic proximity Read ↗

New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.Semantic proximity Read ↗

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Activated protein C resistance--a major risk factor for thrombosis.Semantic proximity Read ↗

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Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

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