Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.

doi:10.1007/s002770050157

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Article

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.

Annals of hematology - 1 Apr 1996

Dahlbäck B, Hillarp A, Rosen S, Zöller B

Abstract excerpt

Vitamin K-dependent protein C is an important regulator of blood coagulation. After its activation on the endothelial cell surface by thrombin bound to thrombomodulin, it cleaves and inactivates procoagulant cofactors Va and VIIIa, protein S and intact factor V working as cofactors. Until recentl...

Topics

Alleles
Anticoagulants
Base Sequence
Drug Resistance
Factor V
Humans
Molecular Sequence Data
Point Mutation
Protein C
Risk Factors
Thrombophlebitis

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