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Article

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.

Annals of hematology - 1 Apr 1996

Dahlbäck B, Hillarp A, Rosen S, Zöller B

Abstract excerpt

Vitamin K-dependent protein C is an important regulator of blood coagulation. After its activation on the endothelial cell surface by thrombin bound to thrombomodulin, it cleaves and inactivates procoagulant cofactors Va and VIIIa, protein S and intact factor V working as cofactors. Until recently, genetic defects of protein C or protein S were, together with antithrombin III deficiency, the established major...

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PMID: 8624369
DOI: 10.1007/s002770050157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.PMID 8624369Read ↗

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Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.Semantic proximity Read ↗

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New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance--a major risk factor for thrombosis.Semantic proximity Read ↗

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Resistance to activated protein C due to factor V R506Q mutation as a cause of venous thrombosis.Semantic proximity Read ↗

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