Article
Apolipoprotein E and Alzheimer's disease.
Annual review of neuroscience - 1 Jan 1996
Strittmatter W J, Roses A D
Abstract excerpt
The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrast, the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset....
Topics
- Age of Onset
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Gene Frequency
- Genetic Linkage
- Genetic Variation
- Genotype
- Humans
- Neurites
- Neurofibrillary Tangles
- Probability