Article
The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.
Biochimica et biophysica acta - 26 Jul 2000
Saunders A M, Trowers M K, Shimkets R A, Blakemore S, Crowther D J, Mansfield T A, Wallace D M, Strittmatter W J, Roses A D
Abstract excerpt
The association of inheritance of different apolipoprotein E (APOE, gene; apoE, protein) alleles with the risk and rate of onset of Alzheimer's disease (AD) is now well established and widely confirmed. While there are now a collection of hypotheses concerning the specific relationship of APOE polymorphisms to various phenotypic manifestations of AD, no single compelling theory has been tested and universally...
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