The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.

doi:10.1016/s0925-4439(00)00035-1

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Article

The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.

Biochimica et biophysica acta - 26 Jul 2000

Saunders A M, Trowers M K, Shimkets R A, Blakemore S, Crowther D J, Mansfield T A, Wallace D M, Strittmatter W J, Roses A D

Abstract excerpt

The association of inheritance of different apolipoprotein E (APOE, gene; apoE, protein) alleles with the risk and rate of onset of Alzheimer's disease (AD) is now well established and widely confirmed. While there are now a collection of hypotheses concerning the specific relationship of APOE polymorphisms to various phenotypic manifestations of AD, no single compelling theory has been tested and universally...

Topics

Alleles
Alzheimer Disease
Animals
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Brain
Disease Models, Animal
Gene Expression Regulation
Gene Targeting
Genetic Techniques
Genotype
Humans
Polymorphism, Genetic
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 10899434
DOI: 10.1016/s0925-4439(00)00035-1

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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