Article
-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.
Journal of inflammation - 1 Jan 2000
Stuber F, Udalova I A, Book M, Drutskaya L N, Kuprash D V, Turetskaya R L, Schade F U, Nedospasov S A
Abstract excerpt
Tumor necrosis factor (TNF) is recognized as a central mediator of sepsis, septic shock, and multiple organ failure. These host reactions are associated with increased TNF levels in circulation, presumably due to increased TNF production. A previously described nucleotide variation at position -308 in the promoter region of the human TNF gene was shown to be associated with the clinical outcome of malaria. In...
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